The ALS Association Wisconsin Chapter’s Board of Directors selects the research projects that we fund, from grants submitted to, reviewed and approved by the ALS Association’s Scientific Review
Committee, Research Committee and Board of Trustees.

 

Either click on the year(s) below or scroll down to read about the important scientific projects
the Chapter has funded since 2008.

2016

  • “ The ALS Association and Cedars-Sinai Stem Cell Center.” Primary researcher: Clive Svendsen, PhD, Cedars-Sinai, Los Angeles, California. This is a collaborative project focusing on the production of new induced pluripotent stem cells (iPS). It is derived in part from Dr. Svendsen’s “Jeff Kaufman Project,” a non-embryonic stem cell research study at UW-Madison’s Waisman Center. The study involved taking adult human skin cells, including those of Jeff Kaufman, and reprogramming them to produce iPS cells. The Evening of Hope funded the Jeff Kaufman Project in 2008 and 2009.

2015

  • "The ALS Association and Cedars-Sinai Stem Cell Center.” Primary researcher: Clive Svendsen, PhD, Cedars-Sinai, Los Angeles, California. This is a collaborative project focusing on the production of new iPS cells and is derived from Dr. Svendsen’s “Jeff Kaufman Study” using Jeff’s skin cells.

  • "Pharmacodynamic study of retigabine (ezogabine) on neural excitability in ALS subjects.” Primary researcher: Brian J. Wainger, MD, PhD, Massachusetts General Hospital, Pain Management Center, Boston, Massachusetts.

2014

  • “Identifying Drugs That Restore NF Levels and Inhibit NF Aggregation in ALS Patient Motor Neurons.” Primary researcher: Su-Chun Zhang, M.D., Ph.D., University of Wisconsin Waisman Center, Madison, Wisconsin.

  • “Application of Human Skeletal Muscle Stem Cells to Treat and Understand ALS.” Primary researcher: Masatoshi Suzuki, Assistant Professor, Department of Comparative Biosciences, University of Wisconsin, Madison, Wisconsin.

  • “Proteostatic Regulation by Ubiquilins in ALS.” Primary researcher: Randall Tibbetts, Associate Professor, University of Wisconsin, Madison, Wisconsin.

2013

  • “Development of a Public Searchable Variant Database for ALS Exomes.”  Primary researcher: John Landers, Ph.D.

 

  • “Developing Small Molecule Screening Assays for Identifying Potential Therapeutics to Treat ALS.” Primary researcher: Jill Zitzewitz, Ph.D.

2012

  • “Proteostatic Regulation by Ubiquillins in ALS.” Primary researcher: Randall Tibbetts, Associate Professor, University of Wisconsin, Madison, WI

 

  • “Generation and Characterization of ALS IPSC Derived Skeletal Muscle.” Primary researcher: Allison Ebert, Ph.D., Assistant Professor, Medical College of Wisconsin, Wauwatosa, WI

 

  • “Developing Cellular and Animal Models of Mutant c9orf72 Mediated ALS-FTD.”  Primary researchers: conducted by researchers at the University of Massachusetts, & the MRC Center for Neurodegeneration Research at King’s College, London, UK

 

  • “Therapy Development for C9orf72 Related Disease: An Antisense Oligonucleotide- Based Approach.” Primary researchers: Michael Benatar, M.D., Zane Zeier, Ph.D., Claes Wahlestedt, M.D., Ph.D., University of Miami Miller School of Medicine, Miami, FL.

2011

  • “Combining Stem Cell and Growth Factor Delivery Targeting to the Skeletal Muscle in ALS.”  Primary researcher: Masatoshi Suzuki, Assistant Professor, Department of Comparative Biosciences, University of Wisconsin, Madison, WI

 

  • “The Role of TDP-43 in Axonal nRNA Trafficking and Local Translation in Healthy and Diseased Motor Neuron.” Primary researcher: Wilfried Rossoli, Ph.D., Emory University, Atlanta, GA

 

  • “Therapy of ALS Based on Peripheral Ly6Chi Monocyte Abnormalities in ALS.” Primary researchers: Howard Weiner, M.D., and Oleg Butovksy, M.D., Brigham & Women’s Hospital, Boston, MA

2010

  • “Modeling Human Motor Neuron Degeneration Using Stem Cells.” Primary researcher Su-Chun Zhang, M.D., Ph.D., University of Wisconsin Waisman Center, Madison, WI*

 

  • “Astrocyte Motor Neuron Interaction: Roles of Nrf2, Glutathione and Oxidative Stress in ALS.” Primary researcher: Jeffrey Johnson, Ph.D., University of Wisconsin, Madison, WI*

 

  • The Motor Neuron Phenotype-Genotype Correlation Study in Patients with Mutant VCP. Primary researchers: Michael Benatar of the University of Miami and J. Paul Taylor of St. Jude’s Children’s Research Hospital.*

 

  • Identification of Familial ALS Genes by Exome Sequencing. Primary Researchers: Bryan J. Traynor of NIH and Adriano Chiò of Torino, Italy.*

        

        *Co-funded with The ALS Association’s Abendroth ALS Genetic Discovery Fund.

2009

  • “The Jeff Kaufman Project.” A non-embryonic stem cell research study involving taking adult human skin cells, including those of Jeff Kaufman, reprogramming them and producing induced pluripotent stem (iPS) cells. Primary researcher: Clive Svendsen, University of Wisconsin Waisman Center, Madison, WI

 

  • “Modeling Human Motor Neuron Degeneration Using Stem Cells.” Primary researcher Su-Chun Zhang, M.D., Ph.D., University of Wisconsin Waisman Center, Madison, WI.* This was a non-embryonic stem cell research study that involved adult human skin cells.

 

  • “Astrocyte Motor Neuron Interaction: Roles of Nrf2, Glutathione and Oxidative Stress in ALS.” Primary researcher: Jeffrey Johnson, Ph.D., University of Wisconsin, Madison, Wisconsin.*

 

        *Co-funded with The ALS Association’s Abendroth ALS Genetic Discovery Fund.

2008

  • “The Jeff Kaufman Project.” This was a non-embryonic stem cell research study that involved taking adult human skin cells, including those of Jeff Kaufman, and reprogramming them to produce induced pluripotent stem (iPS) cells. Primary researcher: Clive Svendsen, University of Wisconsin Waisman Center, Madison, WI

ALS ASSOCIATION WISCONSIN CHAPTER  •  3333 NORTH MAYFAIR ROAD, SUITE 104  •  WAUWATOSA, WI 53222-2319  •  414.763.2220

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